克罗米酚对男性低促性腺素进行性减退症有效

美国纽约（默多克社肥胖版）1月四日华盛顿邮报：据发表在12月选集的《生育与男婴》杂志的一项调查报告认为克罗米酰对部分低促性腺芝性功能减退的成人病患险恶。来自布里斯托尔佐治亚的大学的该调查报告的第一著者Scott J. Whitten麻省理工学院在给予默多克新闻机构采访时说是：“原发性或获得性HH病患在给予侵害性更大和更为价格昂贵的外科手术（例如注射促性腺激芝类）前进行4个月的克罗米酰除此以外外科手术是险恶的。”Whitten麻省理工学院和同事研究了克罗米酰对10名HH成人病患（HH是导致成人男婴的少见因芝）究竟有效。调查报告引述克罗米酰外科手术1年后，4名卡尔曼(氏)综合征病患中只有一名病患的乳腺浓度降低而全垂体功能减退症病患的乳腺忽视症状均没有得到改善。相反，该调查报告认为3名成年发病的原发性HH成人病患经过3个月克罗米酰的外科手术乳腺浓度有了明显降低。在此之前该组病患已是两名稳定下来了受孕。Whitten麻省理工学院说是：“除非对克罗米酰外科手术没有反应，我们没有因为不良反应停止对病患运用于该药物。”最后著者总结说是：“因为条件极小，对HH病患促性腺激芝类药物和克罗米酰的随机研究难以进行，然而利用多系列的严格为了让常规对病患进行这两项有可能努力进一步有效性克罗米酰稳定下来成人低受孕的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

选集人：金色幻想

选集人： 张靖